glutamine and glutathione synthesis (Gln) is converted to glutamate (Glu) by glutaminase, encoded Frontiers | Glutaminolysis and CD4+
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The mechanism is scientifically sound and consistently supported by animal data, but human efficacy and safety have not been established through clinical trials
Int J Prev Med 11, 170.Google Scholar v
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Soluble Vpr released from infected microglia induces oxidative stress, disrupts cellular signaling, and impairs neuronal glutamate transmission [135, 137]
