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Initially identified in research examining delta-wave sleep patterns, DSIP has been investigated for its interaction with neuroendocrine signaling pathways

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For patients being treated with adalimumab, for example, only 19% of patients with moderate to severe ileocolonic CD at 52 weeks demonstrated deep remission ( TNF-like ligand 1A (TL1A), encoded by the gene TNFSF15, has emerged as a cytokine potentially involved in IBD pathogenesis

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