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Hydrogen peroxide induces cellular senescence and FOXO4 nuclear translocation in TM3 Leydig cells To study the role of FOXO4 in regulating Leydig cell senescence in vitro , we induced cell senescence in TM3 mouse Leydig cells using hydrogen peroxide (H 2 O 2 )

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Then Bennett et al
10.1038/s41598-024-57023-z Sci Rep

However, no visible reduction in CMH burden was detected in SS-31-treated aged hypertensive mice based on visual assessment
