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Simultaneously, angiogenesis-related factors induce macrophage polarization toward the M2 phenotype, thereby leading to the development of an immunosuppressive tumor microenvironment (TME)

doi: 10.3390/ijms23105511 373 AhmadRAl-MassAAtizadoVAl-HubailAAl-GhimlasFAl-AroujMet al

Some individuals naturally higher or lower receptor expression affecting sensitivity

Berendsen, C

While challenges in translating findings from animal models to human patients due to differences in important factors such as IVD size, cell turnover, and biomechanical load need to be acknowledged and carefully considered, the usefulness of these experimental models cannot be ignored