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Therefore, the designed mitochondrion-targeting nanoparticle can improve mitochondrial enrichment of Fe-ISAzyme and mitochondrial number, which is beneficial to maximize their therapeutic effect

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Ceramide synthases (CerS) catalyze the acylation of dihydrosphingosine to dihydroceramide

By modifying Keap1 cysteine residues, ITCs stabilize Nrf2, leading to enhanced transcription of antioxidant response elements and phase II detoxification enzymes (113)

Statistics show that LOX gene mutations are the second most common cause of ARCI (Krieg and Furstenberger, 2014)