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highlighted that the rapid turnover of synovial fluid poses a challenge to sustained expression, underscoring the importance of incorporating physical carriers to protect and localize gene payloads (180)

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Looking forward, a promising direction involves developing algorithms that map zebrafish inflammatory scores to clinical biomarkerssuch as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or fecal calprotectin (Liu et al., 2020