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Human glutamylcysteine synthetase protects HEK293 cells against UV-induced cell death through inhibition of c-Jun NH2-terminal kinase

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The best-ranked pose was selected as the final binding mode

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Glutathione is often referred to as the master antioxidant due to its powerful detoxifying properties

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It is currently proposed that liver-derived -HB activates the forkhead box O3 (FoxO3a)/metallothionein 2 (MT2) antioxidant pathway by inhibiting histone deacetylases (HDACs)

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