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Co-administration of AAV vector and 19 M hydroxychloroquine via subretinal injection in mice led to improved transgene expression compared with vector alone using both an AAV2 vector with a ubiquitous CAG promoter (4.6-fold improvement) and an AAV8(Y733F) vector with a photoreceptor-specific promoter (GRK1) (5.9-fold improvement) [111]

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Oral and injectable formulations of existing drugs often exhibit poor bioavailability, systemic toxicity, and suboptimal patient adherence due to frequent dosing and adverse effects (e.g., gastrointestinal distress and rashes) (Yang Y

There were 516 DEGs in endothelial cell/pericytes, with 25 Fr-DEGs identified (Fig