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Similarly, cannabidiol (CBD), which also directly influences endocannabinoid transmission, diminishes ROS accumulation, activates the Nrf2 pathway through NF-kB inhibition and downregulates oxidative enzymes [124, 125]

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Alteration of neurotransmitter systems BBB disruption in schizophrenia leads to neurochemical imbalances, significantly impacting neurotransmitter systems essential for CNS homeostasis, and contributing to a wide range of symptoms including hallucinations, delusions, social withdrawal, apathy and cognitive deficits
Kim MS, Yamashita K, Baek JH

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