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Redox Biol 70:103064 Zhuang Z et al (2024) Inhibition of gasdermin D S-palmitoylation by Disulfiram is crucial for the treatment of myocardial infarction

This mitochondrial targeting enhances copper uptake by 50% compared to non-targeted analogs, leading to pronounced DAMP release and M1 macrophage polarization

This localized phenomenon profoundly underscores the specific remodeling of the local endocrine microenvironment by inflammation: (104)

The displaced lens impairs vision and predisposes the patient to secondary complications, such as myopia, glaucoma, retinal detachment and eventual permanent vision loss

[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Songyang Z, Blechner S, Hoagland N, Hoekstra MF, Piwnica-Worms H, Cantley LC