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ER is the predominant estrogen receptor in the intestinal tract
Also, since you need stomach acid to absorb B12, long-term use of acid-suppressing proton pump inhibitors (such as Nexium, etc.) can lead to B12 deficiency, as can chronic intestinal conditions such as Crohns disease, celiac disease, and intestinal parasites

Hooda Z, Langburt D, Ries S, Antonoff M , Mehran R, Rajaram R, Rice D, Swisher S, Vaporciyan A, Walsh G, Mitchell K, Ferri L, Hofstetter W

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