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ABHD5 ligands that release ABHD5 from PLIN1 or PLIN5 independent of PKA activation, led to the discovery of long-chain acyl-CoA (LC-CoA) as an endogenous allosteric regulator of ABHD5 that promotes the interaction with PLIN1/5 (48)
They perform best when layered onto progressive resistance training, adequate protein, balanced macros, and consistent sleep and stress management
These formulations have limited evidence supporting their superiority over standard oral tablets
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