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Within the technique of immunohistochemistry, special mention must be made of preferentially expressed antigen in melanoma antibody (PRAME), whose expression in the nucleus should give cause for concern in the case of a histologically atypical melanocytic lesion.74,75 Staining with PRAME should not be evaluated in absolute terms (positive/negative), but rather in relative terms (intensity and percentage of staining)

Post-stroke, therapeutic hypothermia so far did not translate into clinically applicable therapies due to hypothermia-associated side-effects compromising patient outcome

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These definitional features must be kept in mind because not uncommon in clinical practice are broad and irregular lentiginous melanocytic proliferations of the trunk and the proximal limbs, mostly found in elderly patients, which are probably the clinicopathological counterpart of lentigo maligna on non-chronically sun-exposed skin and are called lentiginous melanoma (68, 69)