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however, they were seen when administered in conjunction with testosterone at high doses ( In a long-term study (10 years follow-up), including 86 patients with adult-onset pituitary disease who received HGH replacement therapy, four patients died, one from renal carcinoma, one from omental cancer, one from pulmonary edema (probably secondary to an acute myocardial infarction), and a fourth from cerebral infarction

Lv S, Chen X, Chen Y, et al

After supplementation with 10% glycerol, aliquots of purified protein were flash-frozen in liquid nitrogen and stored at 80 C until further use

However, their clinical translation is limited by challenges in intracellular delivery to target cells and the potential for off-target gene silencing effects in non-target tissues

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