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Nicotine acetylcholine receptors (nACHRs) (Ni et al., 2013) and using an antagonist of 7nAChR can actually inhibit the proliferation of microglia and reduce the expression of inflammatory factors IL-1 and TNF- (Poorthuis et al., 2009), improves neuronal plasticity in the hippocampus (Motaghinejad et al., 2016), and can treat excitotoxicity at low concentrations (Sieber, 2012)

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Neuropsychopharmacology 39:27422749 Cavalcante DP, dos Santos Nunes A, Silva ER, de Carvalho GA, Chiarelli RA, Oliveira-Lima OC, Leoncini GO, Ulrich H, Gomez RS, Pinto MCX (2024) GlyT1 inhibition promotes neuroprotection in the middle cerebral artery occlusion model through the activation of GluN2A-containing NMDAR

After use, it can combine with some heavy metals and other substances on the skin, so it can help the skin detoxify well, bring the effect of whitening and skin care, remove some free radicals on the skin, and delay the aging of the skin