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Guyatt GH, Oxman AD, Vist G, et al

This not only serves as additional energetic resource, but also generates a number of biologically active molecules such as diacylglycerol, cholesterol, ceramide, sphingosine, PIP2, IP3 which are involved in the activation of a variety of signaling pathways associated with cancer progression, metastases and therapy resistance e.g

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Minoxidil has neuroprotective effects against paclitaxel in primary cultured DRG neurons and alleviated paclitaxel-induced CIPN by inhibiting neuroinflammation and remodeling the dysregulation of intracellular calcium homeostasis in DRG neurons ( Inhibitor of OCT2 Transporter Activity The screening of a large-scale bioactive compound library (8,086 compounds) identified the FDA-approved TKI dasatinib as a potent inhibitor of the OCT2 transporter, which is involved in oxaliplatin uptake to the DRG (Sprowl et al., 2016)

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