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TMZ functions by methylating adenine and guanine at specific sites within the DNA sequence, resulting in the formation of three methylated products: N7-MeG, N3-MeA, and O6-meG

During a phase 1, multicenter, safety and tolerability study, patients within the high-dose treatment cohort showed continued decline of GA lesion growth rate over the course of 24 months

Additionally, lipid peroxidation, as indicated by MDA levels, was elevated after DSS induction but significantly decreased following QCHS treatment (Fig

This distinction matters for patients who want regenerative results rather than just controlled damage