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This was also observed even after adjustment for major CVD risk factors among patients without metabolic conditions such as diabetes mellitus, hypertension, and dyslipidemia

doi: 10.22037/ijpr.2020.1100952

Med 2:851863.e3, 2021

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Patients with Known or Suspected Mitochondrial Disease Depakote is contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder [see Contraindications (4)]