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Overall, these findings underscore the complexity of the molecular interactions with the neural circuitry underlying anxiety and highlight the necessity for a multifaceted approach in the design of anxiolytic treatments

Chronic inflammatory syndromes are usually linked with a reduction in Se status and some studies have revealed that patients with cystic fibrosis [39, 83], inflammatory bowel diesease, and acne [84] may have a lower status of Se than healthy controls

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