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However, there is good evidence that, although folic acid binds avidly to this receptor in the choroid plexus, it does not cross the opposite, apical membrane to enter the cerebrospinal fluid (CSF) (78)
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113 A controlled trial that included 38 women with menopausal symptoms given 100 mg Pycnogenol daily and 33 similar women given no treatment for eight weeks found those given Pycnogenol had reduced symptom scores for a subset of six common symptoms: hot flashes, night sweats, mood swings, sleep difficulty, low libido, vaginal dryness, and irregular menstrual periods
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