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For instance, pegylated FGF-21 analogs have demonstrated promising results in treating NAFLD [279], while recombinant FGF-21 (rFGF-21) has demonstrated the ability to ameliorate BBB damage caused by T2DM [286]

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Although some NADPH-driven reductions are catabolic, more generally NADPH is the electron donor for anabolic reduction reactions and, accordingly, hundreds of reductive enzymes (reductases) are known to be NADPH-dependent
