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We run the GSH program and the APAP program together - they share the substrate GSH, which is drawn down by the overdose and replenished by the GSH synthesis pathway

Bcl-2 antisense oligodeoxynucleotide (Genasense) enhanced gemtuzumab ozogamicin (Mylotarg)-induced cytotoxicity in acute myeloid leukemia

10.1152/ajpendo.00361.2010 72 KangH

The beneficial microflora can also produce many metabolic products that moderate the interaction between the epithelium and the immune system and generate antimicrobial substances, inhibiting pathogens [14]

Studies on pharmacokinetics [25] and renal clearance of TMAO [26] in healthy human subjects suggest that TMAO has a small volume of distributionabout one half that of ureabut a higher renal clearance compared to urea and creatinine