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Different mechanisms contribute to motor cortex hyperexcitability in amyotrophic lateral sclerosis
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Therefore, its impact is unknown
Each symptom was scored on a 4-point scale (0 = absent, 1 = infrequent, 2 = frequent, 3 = constant), yielding a total Symptom Score (SS) ranging from 0 to 30, reflecting overall symptom burden and impact on QoL
