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However, they still work by inhibiting COX enzymes locally

The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, protein binding, active metabolites, and receptor interactions

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[DOI] [PubMed] [Google Scholar] 63.Shimizu S., Kitada M., Ishikawa H., Itokazu Y., Wakao S., Dezawa M

Pharmacokinetics, distribution, metabolism, and excretion of bodyprotective compound 157 (BPC 157), a potential drug for treating various wounds, in rats and dogs. Frontiers in Pharmacology , 13 , Article 102618