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have proposed criteria, including the binding capability to mutant p53, thermostabilizing, antibody (e.g., PAb1620)-mediated visualization of the conformational change of mutant p53 to wild-type form, and up-regulation of genes targeted by p53, which fulfilling them signifies the compound to be a p53 reactivating agent [678]

It has been recently reported that MAT1 negatively regulates cytochrome P450 2E1 (CYP2E1) expression and that Mat1a knockdown-mediated increase in mitochondrial ROS is CYP2E1 dependent 27
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