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The brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB), are essential and common mechanisms for the antidepressant effects of both the parent molecules of ketamines [i.e., S, R()ketamine, S(+)ketamine, and R()ketamine] and their active metabolites [i.e., (2R,6R)-hydroxynorketamine and of S(+)norketamine] (Yang et al., 2019)

Within this complex interplay of neurochemical and neuroinflammatory mechanisms, numerous herbal plants exhibit therapeutic potential by directly modulating these critical pathways to relieve anxiety symptoms (34, 35)

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Although the weight of the liver increased, the hepatocytes did not divide and regenerate and the liver function remained very low

Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases