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Looking to the next generation of obesity treatments, combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the WL and cardiometabolic benefits of GLP-1 RA

Reaching these requires paired liver biopsies at baseline and at the end of treatment, read by blinded pathologists, because as noted above imaging and blood surrogates cannot substitute for histology at the confirmatory stage

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McColl BW, Rothwell NJ, Allan SM

Avoid injecting into the same spot more than once every 4 to 6 weeks