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In the central nervous system, chemotherapeutic agents also induce neuronal hyperexcitability in the spinal dorsal horn and anterior cingulate cortex leading to the development of central sensitization that causes CIPN

Acral lentiginous melanomas are overrepresented, and SCCs may exhibit more aggressive behavior, with metastasis to lymph nodes and internal organs.[228,231] Pathogenic variants in the WRN gene on chromosome 8p12-p11.2 have been identified in approximately 90% of individuals with this syndrome

However, we used leave-one-out sensitivity analysis under a conservative random-effects model to assess the possibility of some bias such as unclear double-randomization or large unbalanced dropout

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We found that forced expression of either Nir2 or SCP2 caused a significant attenuation in the global increase of PA levels that occurs upon PA feeding of either organelle membrane (Fig