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Individual snails were placed in a 40 L aquarium filled with synthetic spring water (5 cm height) for quantifying movement

High oxygen levels can lead to the formation and accumulation of reactive oxygen species (ROS), including superoxide anions (O 2 ), hydrogen peroxide (H 2 O 2 ), and highly reactive hydroxyl radicals (HO), and cause cell damage, affecting their physiological functions (Amaretti et al., 2013)

The classic M1/M2 paradigm is insufficient to describe their phenotypic continuum, making corresponding metabolic states highly dynamic and difficult to target predictably

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Discussion The results of the analyses presented here suggest that parenteral glutamine supplementation has the potential to significantly improve outcomes for ICU patients in Italy, as our model shows that the additional cost of supplemented treatment is more than completely offset by cost savings in hospital care