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Dosing and Protocol Mistakes Starting Too High: Beginners sometimes start with aggressive doses of 1 mg or higher based on the assumption that more is better

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This is especially relevant for people with hormone optimization protocols who may be taking thyroid medications, hormone replacement therapy, or other compounds that depend on consistent absorption patterns

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Without any clear rationale, the study outcome measures were purposefully modified midtrial to alter the findings in favour of their hypothesis (549, 550)