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[148] In 1960, researchers linked folate deficiency to risk of neural tube defects

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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Hendrie D

[DOI] [PubMed] [Google Scholar] 101.Hochgrafe F., Zhang L., OToole S.A., Browne B.C., Pinese M., Porta Cubas A., Lehrbach G.M., Croucher D.R., Rickwood D., Boulghourjian A., et al

Also, in the state of metabolic abnormalities, activated RhoA/ROCK pathway may also damage the endothelial function in CC through other pathways such as promoting the release of inflammatory factors and increasing the inflammatory response in vascular endothelial cells [38], as well as persistently impairing endothelial-dependent vasodilation to reduce endothelial NOS activation by inhibiting the insulin receptor substrate-1/phosphoinositide 3-kinase/protein kinase B pathway [39]