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Early agents such as hexamethonium were the first effective antihypertensives, demonstrating that pharmacologic reduction of blood pressure could prevent cardiac complications (left panel)

Gupta, M., & Sharma, N

This phylogenetic tree had two main branches and various clades (Verma et al., 2015)

10.1371/journal.pone.0248103 71 LautatzisM

It is not considered likely to cause any undesirable effects during pregnancy
