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Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women
Furthermore, the tendon stiffness in the high dose group was significantly lower than that in the PBS group, and tendons with reduced stiffness may result in less efficient force transfer

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B12 Deficiency and Dermatological Symptoms Patients with a vitamin B12 deficiency may notice dermatological symptoms such as hyperpigmentation, vitiligo, or dry, irritated skin

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