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Upon exposure to ultraviolet B wavelength light (UVB: 280nm315nm) from the sun (or from UVA wavelength light from tanning beds), 7-dehydrocholesterol is non-enzymatically (thermal isomerization) converted first to pre-vitamin D 3 and then to vitamin D 3

Molecules 29, 2897

D., Garcia, A

It tampers with key signals, including IL-6/STAT3, NF-B, and ERK1/2, to limit immunosuppressive macrophages and disable cancer-cell survival pathways