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A phase 1 clinical trial in patients with heart failure and reduced ejection fraction showed that a single 4-hour infusion of high-dose SS-31 resulted in significant decreases in left ventricular end-diastolic volume (18 mL) and end-systolic volume (14 mL) compared to placebo, with the temporal correlation between plasma concentrations and cardiac effects supporting a direct pharmacological mechanism

This process results in suppressed levels of NADPH, which in turn leads to an increase in ROS concentrations

Along with RUNX1, transcription of the SLC22A4 gene has also been shown to be regulated by the NF- B transcription factor, and the inflammatory cytokines IL-1 and TNF- (63) , data suggestive of ergothioneine accumulation being part of an orchestrated cellular immune defence

Teichert J, Sohr R, Hennig L, Baumann F, Schoppmeyer K, Patzak U, et al

Emanuelli, D