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During iron overload, NCOA4 is degraded by the ubiquitinproteasome system, leaving cytosolic ferritin free to store iron [89]

10.3389/fimmu.2022.880298 23 El-SherbinyM.EldosokyM.El-ShafeyM.OthmanG.ElkattawyH

Figure 6: Chronic inflammation increases ROS, damaging liver cells and raising GGT levels, which heightens the risk of hypoxia-related tissue damage

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doi: 10.1038/nm.3432 84 DangEVBarbiJYangHYJinasenaDYuHZhengYet al
