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Estrogen-driven collagen decline accelerates during perimenopause, and substrate is typically already more depleted at baseline

Clinical diagnosis of endometriosis should be considered appropriate for typical presentations without requiring surgical confirmation

The effectiveness of oncolytic viruses (OVs) is modest despite good safety

In total, 20136 patients were included in the RCTs and 810939 in the OBS

Generally, the development of novel TCIs entails the introduction of a warhead onto a potent noncovalent scaffold [1,21,32,33,34], or high-throughput screening (HTS) of small molecule covalent ligands [35,36,37] or covalent fragment libraries [31,36,38,39,40,41,42,43], with structure-based lead optimization supported by in silico approaches (e.g., covalent docking, virtual screening [32,44,45,46])