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Allergy-wise, there are some case reports on neem oil causing allergic contact dermatitis so people with plant/botanical sensitivities may want to patch test first
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10.1016/j.celrep.2014.11.016 185 OwusuB

How this might affect TCR tuning or agonist selected cells, such as invariant natural killer T cells (iNKT cells), remains unknown

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
