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Indeed, depletion of CDK2 or inhibition of CDK2-kinase activity in combination with CDK4/6-inhibitors blocked proliferation of CDK4/6-inhibitor resistant cancer cells (111, 141, 158161)

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Real-world example: A backyard barbecue or beach day where drinking happens over several hours in direct sun combines two separate dehydrating forces at once heat and alcohol making this one of the more realistic everyday scenarios where the BAC-concentrating effect is likely to be more than trivial