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Current limitations include the lack of early-phase clinical trials and safety concerns in cirrhotic livers, the lack of specificity and systemic toxicity of available NRF2 inhibitors, the genetic and molecular heterogeneity in HCC tumors, and the absence of validated biomarkers for NRF2 activity and therapeutic response

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Design of peptide-based gene delivery systems to overcome biological barriers

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hESCs were maintained at 37 C with 5% CO 2 and 5% O 2

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Springer: New York, 2020

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