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In mouse renal tissue, the secreted glycoprotein progranulin (PGRN) induces mitobiogenesis and mitophagy through the PGRN-Sirt1-PGC-1/FoxO1 signaling axis, reducing the effects of excessive hyperglycemia on mitochondrial dysfunction [213]
That can slow how the dose is used and is a known issue, particularly in women and larger patients where there is more tissue to pass through
Low iron common in women, worsens shedding
Handb Exp Pharmacol 2014;220:220-3
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