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The linkage to tryptophan consumption is clear as a tryptophan-deficient diet leads to worse EAE symptoms, while restoring dietary tryptophan reverses this effect in MICROGLIAL-AhR sufficient but not deficient mice, suggesting tryptophan metabolites exert their function by activating AhR in the microglia (34)

Hepatic cyp1a inductionin 3-methylcholanthrene-treated transgenic rats with insufficient blood growth hormone

Effects of different dietary interventions in multiple sclerosis: a systematic review of evidence from 2018 to 2022

Such unpredicted responses may be due to release of these two agents in a sequential way

Future Directions and Recommendations Short-Term Implementation Goals Healthcare systems should prioritize implementing standardized clinical assessment protocols within the next 12-18 months