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However, the normal utilization and release of iron are constrained, resulting in elevated production of ROS and a decrease in the biosynthesis of heme and Fe-S clusters during conditions of iron overload [57]
[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Wu Y, Huang L, Sai W, Chen F, Liu Y, Han C, et al
doi: 10.1016/j.cell.2009.09.033
ENO1 suppression could also be associated with apoptosis induction by curcumin probably mediated through p38 mitogen-activated protein kinase (MAPK) activation and 5 adenosine monophosphate-activated protein kinase (AMPK) dephosphorylation [117]
Venkatesan, P
