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Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-B activity in conditions of oxidative stress
doi: 10.1016/j.bbamem.2017.05.017
Recent studies have validated exogenous MG53 (1 mg/kg, single-dose) has been shown to preserve mitochondrial integrity during I/R-induced oxidative stress via binding to the mitochondria-specific phospholipid cardiolipin (CL), thereby preventing ROS and mitophagy for cardioprotection [153]
