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Concurrently, MDA contents were increased at different stages of kidney injury in mice (Figure 2F), providing further evidence for the occurrence of ferroptosis in renal tissues

This approach involved substituting a disulfide bridge with a thioether linkage, with cystathionine being generated in situ from cysteine using orthogonal protection strategies

HLPC-grade acetonitrile and methanol were obtained from Fisher Scientific (Leicester, UK) and used without further purification

The slow cellular uptake and regulatory effects of magnesium are less practical here because the therapeutic window is very narrow, and the rapid physiological changes postinjury require immediate interventions that go beyond magnesium supplementation