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J Biol Chem (2010) 285:40699705.10.1074/jbc.M110.185827 73 TanSXGreethamDRaethSGrantCMDawesIWPerroneGG

NK cells and CD3 + , CD4 + , and CD8 + T lymphocytes are currently thought to be the primary immune cells in the TME, with CD8 + T lymphocytes playing a significant role in tumor killing (83, 84)

Whereas amylin acts via the amylin receptor, a complex of CALCR and one of three receptor activity modifying proteins (RAMP13), cagrilintide binds the amylin receptor and CALCR with similar potency

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(2012) 7:e50568