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High concentrations of C3, present in both RGCs and in the nerve fiber layer, are also associated with RGC and axon degeneration, and its inhibition under chronic elevated IOP leads to neuroprotection, suggesting a role in the development and progression of glaucoma (Kuehn et al., 2006

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For the Fbp1 protein, tetramerization overcomes the weak degron of an individual protomer by enabling avid binding to higher-order GID SR4 assemblies (Chelator or presumably Cage) 22

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