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Furthermore, a randomized, double-blind, controlled study by Manarin et al
Activated microglia undergo morphological changes, adopting an amoeboid-like phenotype with shortened processes and enlarged somata, and polarize into pro-inflammatory M1 or anti-inflammatory M2 subtypes [16]
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79 The ECS consists of two members of the family of receptors coupled to protein G, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), as well as endogenous ligands, among these, the most studied are anandamide and 2-arachidonoylglycerol (2-AG)
Celi, P., 2010
