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"Delaying the mitochondrial decay of aging with acetylcarnitine." Annals of the New York Academy of Sciences

Pharmacol Res 32:383389 [DOI] [PubMed] [Google Scholar] 146.Virmani MA, Caso V, Spadoni A, Rossi S, Russo F, Gaetani F (2001) The action of acetyl-l-carnitine on the neurotoxicity evoked by amyloid fragments and peroxide on primary rat cortical neurones

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The developing brain is much more susceptible to the harmful effects of ammonia than a mature brain.11 Its toxicity is associated to the elevation of extracellular glutamate levels and the development of cerebral oedema with increased intracranial pressure.4 The urea cycle is the main metabolic pathway to eliminate ammonia, transforming it into urea that is later excreted by the kidney