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Moreover, the released all-trans retinoic acid, as a differentiation agent, reduce the cancer stem cells stemness and improve the cancer stem cells enriched microenvironment, offering a synergistic effect for enhanced anti-cancer stem cells treatment of photosensitizer in inhibition of in vivo tumor growth and metastasis

Acta Physiol Plant 41:19

The reaction may show up within minutes or appear gradually over hours

112 These findings collectively suggest that epigenetic remodeling plays a vital role in the anti-ageing process, preventing the activation, and mobilization of retrotransposons by increasing heterochromatin stability

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